Characterisation of bacteria by matrix-assisted laser desorption/ionisation and electrospray mass spectrometry.

Rapid Identification of Anaerobic Bacteria Using Matrix Assisted Laser Desorption Ionisation Time-of-flight Mass Spectrometry

Quantitative Mass Spectrometry: Elucidation of the Transduction Cascade Triggered by B cell Receptors

Mass Spectrometry and Proteomics The above definition presents a challenge to modern mass spectrometry, as the proteome of a cell is not constant, but rather is regulated dynamically. For example, different proteins with different numbers of copies are present during the different stages of cell development, differentiation and proliferation, as well as in the individual subcellular processes. ...

Determination of Cortisol, Cortisone, Prednisolone and Prednisone in Bovine Urine by Liquid Chromatography-electrospray Ionisation Single Quadrupole Mass Spectrometry

Investigation of protein induction in tumour vascular targeted strategies by MALDI MSI.

Characterising the protein signatures in tumours following vascular-targeted therapy will help determine both treatment response and resistance mechanisms. Here, mass spectrometry imaging and MS/MS with and without ion mobility separation have been used for this purpose in a mouse fibrosarcoma model following treatment with the tubulin-binding tumour vascular disrupting agent, combretastatin A-...

Mass Spectrometric Detection of Carcinogen Adducts

Genotoxic carcinogens interact with nucleic acids and proteins to yield covalently bound products (adducts), the quantitative determination of which has been proposed as a biomonitor of human exposure to carcinogens. Mass spectrometry is playing a leading role both in the structural characterisation and in the quantitative determination of these carcinogen adducts. In particular electrospray io...